ORIGINAL ARTICLE Radiation Therapy With or Without Chemotherapy for Cervical Cancer With Periaortic Lymph Node Metastasis

Abstract: The purpose of this article is to evaluate the efficacy of chemoradiation therapy (CRT) and radiation therapy (RT) alone for cervical cancer with periaortic nodal metastasis (PANM). Twenty-one patients with cervical cancer with PANM were identified. Eleven patients received concomitant CRT with cisplatin-based chemotherapy and 10 received RT alone. The median age was 44 years. Ten, 5, and 6 patients had International Federation of Gyne-cology and Obstetrics stages IB, IIB, and IIIB disease. The RT doses to point A and the periaortic region were 80 to 85 Gy (low dose rate equivalent) and 45 Gy. The median follow-up was 26 months (range 3 to 141 months). The 1- and 3-year disease-specific survival were 81.8 % and 81.8%, and 70 % and 30%, respectively, for the CRT and RT groups, (P 0.11). The 1- and 3-year pelvic and periaortic control rates (PPC) were 100 % and 100 % (CRT), and 56.3 % and 42.2 % (RT) (P 0.03). The 1- and 3-year free-from-distant metas