ACTIVATED B CELLS IN THE THYMUS GLAND OF PATIENTS WITH MYASTHENIA GRAVIS

yasthenia gravis (MG) is an autoimmune disease caused by the production of autoantibodies that damage acetylcholine receptors (AchR) at the myoneuronal junction. It is well documented that abnormalities of the thymus gland, including lymphofollicular thymitis and thymoma, may play a role in the pathogenesis of this disease. Association between acetylcholine receptor autoantibodies and thymic changes such as lymphofollicular hyperplasia (LFH) have been widely discussed.1 Although LFH is not pathognomonic for MG, it is the most common pathologic finding. Germinal centers (GCs) found in MG patients are larger and more frequent tha