Printed in Great Britain 293 Studies on Tissue Specificity of Interferon

This study reports the investigation of tissue specificity of interferon induced with Chikungunya virus in lung and kidney cells obtained from 17-day chick embryos. Lung cells produced significantly more interferon than kidney cells under essentially the same conditions. Both lung and kidney interferon preparations repressed plaque formation on homologous and heterologous cells and lung cells were more sensitive to the protective effects of all the interferon preparations tested. No evidence for tissue specificity was obtained