Running Title: Hypertriglyceridemia in LDLR-/- mice

Liver X receptors (LXRs) activate triglyceride synthesis in liver directly and indirectly by inducing sterol regulatory element-binding protein-1c (SREBP-1c). When administered to wild-type mice, the LXR activator T0901317 produces a mild and transient hypertriglyceridemia. Here, we show that T0901317 produces massive hypertriglyceridemia when given to mice lacking LDL receptors (LDLR-/- mice). Triglycerides ranged from 4000-6000 mg/dl, and the plasma turned milky. The median diameter of VLDL particles, measured by electron microscopy, increased from 60 to 112 nm, 87 % exceeding 80 nm, the size o