Add to ORKGOver the past decade, success in the treatment of serious genetic disorders via gene therapy was finally achieved. However, this progress was tempered by the occurrence of serious adverse events related to vector integration into the genome and activation of adjacent proto-oncogenes. Investigators are now focused on retaining the clinical potential of integrating vectors while decreasing the risk of insertional mutagenesis
The concept of gene therapy was introduced with great promise and high expectations. However, what a...
International audienceReplication-defective retroviral vectors have been used for more than 25 years...
The first gene therapy clinical trials were initiated more than two decades ago. In the early days, ...
Gene transfer vectors derived from oncoretroviruses or lentiviruses are the most robust and reliable...
Effective gene-based interventions for the treatment of genetic disorders, neurodegenerative disease...
γ-Retroviral and lentiviral vectors allow the permanent integration of a therapeutic transgene in t...
The curative potential of retroviral vectors for somatic gene therapy has been demonstrated impressi...
Indiana University-Purdue University Indianapolis (IUPUI)Lentiviral vector mediated gene therapy has...
The concept of gene therapy was envisioned soon after the emergence of restriction endonucleases and...
The ability of retroviruses to integrate a precise copy of the viral genome into host cell DNA (deox...
Retroviral vectors, including those derived from gammaretroviruses and lentiviruses, have found thei...
Gene therapy is one of the most attractive fields in medicine. The concept of gene delivery to tissu...
Gene therapy has become a significant issue in science-related news. The principal concept of gene t...
Copyright: © 2009 Alessandro A, et al. This is an open-access article distributed under the terms o...
The many platform and poster presentations at the last annual meeting of the American Society for Ge...
The concept of gene therapy was introduced with great promise and high expectations. However, what a...
International audienceReplication-defective retroviral vectors have been used for more than 25 years...
The first gene therapy clinical trials were initiated more than two decades ago. In the early days, ...
Gene transfer vectors derived from oncoretroviruses or lentiviruses are the most robust and reliable...
Effective gene-based interventions for the treatment of genetic disorders, neurodegenerative disease...
γ-Retroviral and lentiviral vectors allow the permanent integration of a therapeutic transgene in t...
The curative potential of retroviral vectors for somatic gene therapy has been demonstrated impressi...
Indiana University-Purdue University Indianapolis (IUPUI)Lentiviral vector mediated gene therapy has...
The concept of gene therapy was envisioned soon after the emergence of restriction endonucleases and...
The ability of retroviruses to integrate a precise copy of the viral genome into host cell DNA (deox...
Retroviral vectors, including those derived from gammaretroviruses and lentiviruses, have found thei...
Gene therapy is one of the most attractive fields in medicine. The concept of gene delivery to tissu...
Gene therapy has become a significant issue in science-related news. The principal concept of gene t...
Copyright: © 2009 Alessandro A, et al. This is an open-access article distributed under the terms o...
The many platform and poster presentations at the last annual meeting of the American Society for Ge...
The concept of gene therapy was introduced with great promise and high expectations. However, what a...
International audienceReplication-defective retroviral vectors have been used for more than 25 years...
The first gene therapy clinical trials were initiated more than two decades ago. In the early days, ...