COCHRANE CORNER Pharmacological Interventions for Clozapine-induced Hypersalivation

Clozapine is widely used for people with schizophrenia. Agranulocytosis, weight gain, and cardiac problems are serious problems associated with clozapine use. Hyper-salivation, sometimes of a gross and socially unaccept-able quantity, is also common (30%–80%). Objectives To determine the clinical effects of pharmacological interventions for clozapine-induced hypersalivation. Search strategy The Cochrane Schizophrenia Group Trials Register (March 2007) is compiled by systematic searches of major databases, journals, and conference proceedings. Selection criteria All relevant randomized controlled trials. Data collection and analysi