DOCKING STUDIES OF NOVEL 2-[5-SUBSTITUTED-1-H BENZO (d)IMIDAZOLE-2-YL SULFINYL] METHYL 3-SUBSTITUTED QUINAZOLINE-4(3H)ONE

Abstract: In present investigation; we tried to authenticate quinazoline derivatives, which are extensively reported in the literature as antiulcer agent. In doing so we attempted virtual ligand screening; which found more promising as compare to high throughput screening in overcoming the limitations of unprecedented number of novel leads. We selected fifty one novel 2-[5-substituted-1-H benzo(d)imidazole-2-yl sulfinyl]methyl-3-substituted quinazoline-4(3H)one and subsequently docked them into newly generated homology model of H+/K+ ATPase at BioMed CAChe workstation V6.1.1.The analogues 42 and 43 were found promising. Omeprazole is selected as a standard. Structure based drug designing of these analogues may found a novel antiulcer drug at future study