Little Artifices of Huge Libraries: Secrets of Parallel Liquid-Phase Synthesis

Abstract―Key aspects of differences between liquid-phase parallel synthesis and preparation of a single compound at a time are reviewed. Specific technique and equipment is required to make in the parallel manner such processes as heating (involving MW ovens and flow microreactors), extraction, filtration, and chromatography. Rich illustrations may be useful in educational courses on medicinal and combinatorial chemistry. In the previous papers we considered the pos-sibilities of solid-phase synthesis (SPS) of libraries of chemical compounds, and, therewith, some of these methods [1, 2] can be used as training tasks at student laboratories. All manipulations in SPS are in fact limited to two multiply repeated operations: addition of an outside reagent (reaction as such) and its removal (filtering and washing). The technology may slightly vary, but a common feature of all variants is that a reactor is combined with a filter for purification. In thi