Climate and disease

Wilson’s disease is an autosomal recessive disorder of copper metabolism that causes accumulation of copper in liver, brain, and other organs. The disease may present with hepatic or neurological manifestations. We describe a rather uncommon presentation of Wilson’s disease with fulminant hepatic failure and Coomb’s-negative hemolytic anemia. Fulminant hepatic failure due to Wilson’s disease has distinct features, such as relatively low levels of hepatic transaminases and alkaline phosphatase and high levels of serum bilirubin, that distinguish it from other causes of fulminant hepatic failure. Prompt recognition of the symptoms and expedited liver transplantation remain crucial for this otherwise rapidly progressive and fatal disease. ilson’s disease (WD) is an autosomal recessive disorder of copper metabolism that causes accumulation of copper in liver, brain, and other organs. The primary pathogenic mechanism consists of impaired biliary excretion of copper, resulting in copper overload. The prevalence of the disease is approximately 30 per million. Positive copper balance starts i