Lack of Association between Increased Carotid Intima-Media Thickening and Decreased HDL-Cholesterol in a Family with a

versely correlated with cardiovascular disease, and pre-vious studies have demonstrated that variants in the ATP-binding cassette transporter, ABCA1, are responsi-ble for a proportion of HDL-C deficiency states. We identified a novel variant in ABCA1 in a kindred with decreased HDL-C. This variant was not identified in>200 chromosomes of healthy individuals. The pro-band, a heterozygote for G2265T, developed premature coronary artery disease. In addition to low HDL-C, six biological family members heterozygous for the ABCA1 variant exhibited low HDL-C concentrations compared with unaffected family members (0.83 0.32 vs 1.33 0.36 mmol/L; P 0.009). Despite the decreased HDL-C, carotid artery B-mode ultrasound studies failed to reveal increased intima-media thickening in affected individ-uals compared with age- and sex-matched controls