Anti-stress Activity of Mitragyna africanus (Willd), Stembark Extract

The acute toxicity and the effect of Mitragyna africanus stembark extract of methanol (CH OH) on stress were investigated in rats, using its effect on3 pentyleneterazole induced convulsions and its muscle relaxant effect. The extract did not produce any death in the treated rats even at the highest dose (6400mg kg) used. It did not protect rats treated with convulsive doses of-1 pentylenetetrazol (100mg kg) but increased the period of onset of convulsions-1 and decreased the number of spasms. It also showed significant (p<0.05) muscle relaxant effect