Xiaoqing Chen, Nicola Waddell, Nicole Cloonan, The Kathleen Cuningham Consortium for Research

of Investigators of Modifiers of BRCA1/2 (CIMBA)† RAD51 is an important component of double-stranded DNA–repair mechanisms that interacts with both BRCA1 and BRCA2. A single-nucleotide polymorphism (SNP) in the 5 ′ untranslated region (UTR) of RAD51, 135GrC, has been suggested as a possible modifier of breast cancer risk in BRCA1 and BRCA2 mutation carriers. We pooled genotype data for 8,512 female mutation carriers from 19 studies for the RAD51 135GrC SNP. We found evidence of an increased breas