RESEARCH ARTICLE Open Access HIV prevention for South African youth: which

interventions work? A systematic review of current evidence Abigail Harrison1*, Marie-Louise Newell2,3, John Imrie2,4, Graeme Hoddinott2 Background: In South Africa, HIV prevalence among youth aged 15-24 is among the world’s highest. Given the urgent need to identify effective HIV prevention approaches, this review assesses the evidence base for youth HIV prevention in South Africa. Methods: Systematic, analytical review of HIV prevention interventions targeting youth in South Africa since 2000. Critical assessment of interventions in 4 domains: 1) study design and outcomes, 2) intervention design (content, curriculum, theory, adaptation process), 3) thematic focus and HIV causal pathways, 4) intervention delivery (duration, intensity, who, how, where). Results: Eight youth HIV prevention interventions were included; all were similar in HIV prevention content an