and Impaired Insulin Release in 10,705 Danish Subjects Validation and Extension of Genome-Wide Association Studies

OBJECTIVE—In the present study, we aimed to validate the type 2 diabetes susceptibility alleles identified in six recent genome-wide association studies in the HHEX/KIF11/IDE (rs1111875), CDKN2A/B (rs10811661), and IGF2BP2 (rs4402960) loci, as well as the intergenic rs9300039 variant. Furthermore, we aimed to characterize quantitative metabolic risk phenotypes of the four variants. RESEARCH DESIGN AND METHODS—The variants were genotyped in the population-based Inter99 cohort (n 5,970), the ADDITION Study (n 1,626), a population-based sample of young healthy subjects (n 377), and in additional type 2 diabetic case (n 2,111) and glucose-tolerant (n 521) sub-jects. The case-control studies involved a total of 4,089 type 2 diabetic patients and 5,043 glucose-tolerant control subjects. RESULTS—We validated association of variants near HHEX