Add to ORKGBackground. Recent data suggest that aldosterone antag-onists have beneficial effects on diabetic nephropathy. In this study, we investigated the dose-dependent effect of eplerenone and a combined treatment with eplerenone and enalapril compared with each drug alone on renal function in type II diabetic rats. To further explore the molecular mechanism of action of combination therapy, we also per-formed in vitro study. Methods. The animals were divided into six groups as follows: normal control Long-Evans Tokushima Ot-suka (LETO) rats, Otsuka Long-Evans Tokushima Fatty (OLETF) rats, OLETF rats treated with low dose of eplerenone (50 mg/kg/day), OLETF rats treated with high dose of eplerenone (200 mg/kg/day), OLETF rats treate
Reduction of proteinuria and blood pressure (BP) with blockers of the renin-angiotensin system (RAS)...
In this study, we examined the renoprotective effects of curative and prophylactic doses of eplereno...
This study aimed to assess the renopreventive effect of enalapril and/or paricalcitol on streptozoto...
Background. Recent data suggest that aldosterone antag-onists have beneficial effects on diabetic ne...
*Both authors have equal contribution to this work. Background. Several studies in patients with pri...
Aim. To study the effect of eplerenone on the activity of free radical oxidation and renal function ...
Background: One of the major concerns is a nephropathy in diabetes, which applies many different kin...
<p>Uni-nephrectomised rats with an aldosterone mini-pump and on a high salt diet were treated for 4 ...
WOS: 000346268700003PubMed ID: 24941431Background: One of the major concerns is a nephropathy in dia...
Background. Several studies in patients with primary aldosteronism (PA) have suggested that aldoster...
Background. Angiotensin II blockade and spirono-lactone effectively reduces proteinuria in humans. T...
Background. Recent data indicate that aldosterone ag-gravates cyclosporin A (CsA)-induced nephrotoxi...
Background/Aims: Prolonged elevation of serum aldosterone leads to renal fibrosis. Inflammation also...
Background/Aims: The search for new therapies providing cardiorenal protection in chronic kidney dis...
WOS: 000341298100018PubMed ID: 25010195Hyperglycemia, hypertension, dyslipidemia, and inflammation h...
Reduction of proteinuria and blood pressure (BP) with blockers of the renin-angiotensin system (RAS)...
In this study, we examined the renoprotective effects of curative and prophylactic doses of eplereno...
This study aimed to assess the renopreventive effect of enalapril and/or paricalcitol on streptozoto...
Background. Recent data suggest that aldosterone antag-onists have beneficial effects on diabetic ne...
*Both authors have equal contribution to this work. Background. Several studies in patients with pri...
Aim. To study the effect of eplerenone on the activity of free radical oxidation and renal function ...
Background: One of the major concerns is a nephropathy in diabetes, which applies many different kin...
<p>Uni-nephrectomised rats with an aldosterone mini-pump and on a high salt diet were treated for 4 ...
WOS: 000346268700003PubMed ID: 24941431Background: One of the major concerns is a nephropathy in dia...
Background. Several studies in patients with primary aldosteronism (PA) have suggested that aldoster...
Background. Angiotensin II blockade and spirono-lactone effectively reduces proteinuria in humans. T...
Background. Recent data indicate that aldosterone ag-gravates cyclosporin A (CsA)-induced nephrotoxi...
Background/Aims: Prolonged elevation of serum aldosterone leads to renal fibrosis. Inflammation also...
Background/Aims: The search for new therapies providing cardiorenal protection in chronic kidney dis...
WOS: 000341298100018PubMed ID: 25010195Hyperglycemia, hypertension, dyslipidemia, and inflammation h...
Reduction of proteinuria and blood pressure (BP) with blockers of the renin-angiotensin system (RAS)...
In this study, we examined the renoprotective effects of curative and prophylactic doses of eplereno...
This study aimed to assess the renopreventive effect of enalapril and/or paricalcitol on streptozoto...