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Acetate, cacodylate, phosphate and imidazole are well known as the bifunctional acid and base catalysts. Catalysis of these bifunctional catalysts depends on the structure of the reaction substrates. For example, in nucleophilic substitution reaction at the carbonyl carbon, imidazole has been found to be 100-4000 fold as reactive as phosphate dianion,1 whereas imidazole and phosphate dianion or imidazolium and phosphate monoion exhibit nearly equal effect in the general acid or general base catalysis in nucleophilic substitution reactions of imine derivatives.2,3 However, there are little reports on the catalysis of acid and base bifunctional catalysts for the hydrolysis of amides. So, we have performed the hydrolysis of N-benzoyl-4(5)-methylimidazole (1) and N-toluoyl-4(5)-methylimidazole (2) to compare with the structure of substrate and th