Add to ORKGD ow nloaded from Aim: The aim of this study was to analyze the mRNA expression levels and protein distribution of the cardiac sodium channel Scn5a/Nav1.5 during mouse cardiogenesis. Methods: Scn5a mRNA levels were determined by real-time RT-PCR using embryonic hearts ranging from E9.5 to E17.5 as well as postnatal and adult hearts. In addition, Scn5a protein (Nav1.5) distribution was analyzed by immunohistochemistry and confocal microscopy. Results: Scn5a mRNA levels displayed a peak at stage E11.5, decreased during the subsequent stages and then steadily increased from E17.5 onwards, and throughout the postnatal to the adult stages. Immunohistochemistry experiments revealed comparable distribution of Nav1.5 between the different cardiac c...
The main cardiac voltage-gated Na+ channel, Nav1.5, plays a key role in generation of the cardiac ac...
This study examined the diversity of Na ' channel gene ex-pression in intact cardiac tissue and...
AbstractThe aim of this mini-review is to draw together the main concepts and findings that have eme...
Cardiac sodium channels are responsible for conduction in the normal and diseased heart. We aimed to...
(A) mRNA levels of Scn5a (Nav1.5) sodium channel, Slc8a1 (Ncx1) sodium calcium exchanger, Pln, Cacna...
Background: Embryonic cardiomyocytes undergo profound changes in their electrophysiological properti...
During the past decade, Nav1.5, the main voltage-gated Na+ channel in the heart, has been shown to b...
Rationale: Voltage-gated sodium channels initiate action potentials in excitable tissues. Mice in wh...
During the past decade, Na(v)1.5, the main voltage-gated Na(+) channel in the heart, has been shown ...
During the past decade, Na(v)1.5, the main voltage-gated Na(+) channel in the heart, has been shown ...
The gene SCN5A encodes the main cardiac sodium channel NaV1.5. This channel predominates the cardiac...
Voltage gated sodium channels (VGSC) conduct the sodium current responsible for the rapid upstroke o...
<p>(A) Atrial; (B) ventricular. Connexins and sodium channels genes expression levels were assessed ...
Nav1.5 is the predominant cardiac sodium channel subtype, encoded by the SCN5A gene, which is involv...
The main cardiac voltage-gated Na+ channel, Nav1.5, plays a key role in generation of the cardiac ac...
The main cardiac voltage-gated Na+ channel, Nav1.5, plays a key role in generation of the cardiac ac...
This study examined the diversity of Na ' channel gene ex-pression in intact cardiac tissue and...
AbstractThe aim of this mini-review is to draw together the main concepts and findings that have eme...
Cardiac sodium channels are responsible for conduction in the normal and diseased heart. We aimed to...
(A) mRNA levels of Scn5a (Nav1.5) sodium channel, Slc8a1 (Ncx1) sodium calcium exchanger, Pln, Cacna...
Background: Embryonic cardiomyocytes undergo profound changes in their electrophysiological properti...
During the past decade, Nav1.5, the main voltage-gated Na+ channel in the heart, has been shown to b...
Rationale: Voltage-gated sodium channels initiate action potentials in excitable tissues. Mice in wh...
During the past decade, Na(v)1.5, the main voltage-gated Na(+) channel in the heart, has been shown ...
During the past decade, Na(v)1.5, the main voltage-gated Na(+) channel in the heart, has been shown ...
The gene SCN5A encodes the main cardiac sodium channel NaV1.5. This channel predominates the cardiac...
Voltage gated sodium channels (VGSC) conduct the sodium current responsible for the rapid upstroke o...
<p>(A) Atrial; (B) ventricular. Connexins and sodium channels genes expression levels were assessed ...
Nav1.5 is the predominant cardiac sodium channel subtype, encoded by the SCN5A gene, which is involv...
The main cardiac voltage-gated Na+ channel, Nav1.5, plays a key role in generation of the cardiac ac...
The main cardiac voltage-gated Na+ channel, Nav1.5, plays a key role in generation of the cardiac ac...
This study examined the diversity of Na ' channel gene ex-pression in intact cardiac tissue and...
AbstractThe aim of this mini-review is to draw together the main concepts and findings that have eme...