BASIC SCIENCE INVESTIGATIONS Comparison of 1-11C-Glucose and 18F-FDG for Quantifying Myocardial Glucose Use with PET

In this study, we compared the accuracy of the rate of myocar-dial glucose use (rMGU) measured using PET and 1-11C-glu-cose with the rate measured using PET and the more con-ventional tracer 18F-FDG. Methods: PET measurements of myocardial tracer uptake (K, in mL/g/min) and rMGU (in nmol/ g/min) were obtained with 1-11C-glucose and 18F-FDG in 21 dogs using kinetic modeling and the Patlak graphical method, respectively. Eighteen dogs were studied during hyperinsulin-emic–euglycemic clamp performed either at rest or combined with phenylephrine, dobutamine, intralipid infusion, or intralipid infusion and dobutamine. Three dogs were studied during in-tralipid infusion alone under resting conditions. Arterial–coro-nary sinus sampling was performed to measure the K of both tracers (n 14) and rMGU by the Fick method (n 21). Results: PET-derived values for K from either 1-11C-glucose o