681 INTRAPERITONEAL CALCITRIOL IN INFANTS ON PERITONEAL DIALYSIS

¤ Background: Calcitriol has long been used as the main therapy in renal osteodystrophy, but the efficacy of the oral route is not always as high as expected. ¤ Objective: To asses the safety and efficacy of intraperito-neal calcitriol in infants undergoing peritoneal dialysis (PD). ¤ Patients and Methods: PD patients on oral calcitriol therapy, with serum parathyroid hormone (PTH)>1000 pg/mL during the previous 3 months of treatment, were switched to intraperitoneal calcitriol therapy, 1 mm mm m g twice per week. Dose was increased to 1 mm mm m g three times per week if PTH remained>1000 pg/mL, and was later readjusted. Target PTH was 200 – 300 pg/mL according DOQI guidelines. Statistics: All results are expressed as mean ± SE. The Wilcoxon signed rank test was used to evaluate differences in measurements for each pair of values. The confidence interval for differences between population medians was 96.9%. A p value less than 0.05 was considered significant. ¤ Results: Six male children, mean age 17 ± 3.86 months