ARTICLE Large Cohort Study of Aspirin and Other Nonsteroidal Anti-infl ammatory Drugs and Prostate Cancer Incidence

infl ammatory drugs (NSAIDs) has consistently been associ-ated with a reduced risk of colon cancer. Recent epidemiologic studies have suggested that the use of NSAIDs, particularly aspirin, may also be associated with a reduced risk of prostate cancer, but the evidence remains limited. Methods: We examined the association between NSAID use and pros-tate cancer incidence among 70 144 men in the American Cancer Society’s Cancer Prevention Study II Nutrition Cohort. Information on NSAID use was obtained from a questionnaire completed at study enrollment in 1992 – 1993 and was updated using follow-up questionnaires in 1997 and 1999. We calculated rate ratios (RRs) and 95 % confi-dence intervals (CIs) for prostate cancer incidence associ-ated with NSAID use, adjusting for age and potential prostate cancer risk factors. Results: During follow-up fro