doi:10.1093/nar/gkn323 Onto-CC: a web server for identifying Gene Ontology conceptual clusters

The Gene Ontology (GO) vocabulary has been exten-sively explored to analyze the functions of coex-pressed genes. However, despite its extended use in Biology and Medical Sciences, there are still high levels of uncertainty about which ontology (i.e. Molecular Process, Cellular Component or Molecular Function) should be used, and at which level of specificity. Moreover, the GO database can contain incomplete information resulting from human annotations, or highly influenced by the avail-able knowledge about a specific branch in an ontol-ogy. In spite of these drawbacks, there is a trend to ignore these problems and even use GO terms to conduct searches of gene expression profile