Pregnancy with Oocyte Donation and In-vitro Fertilization in a Woman with Premature Ovarian Failure

A twenty eight year old nulliparous Bahraini lady, presented with four years history of primary infertility and thirteen years history of secondary amenorrhoea. A diagnosis of premature ovarian failure was made. She was advised to take hormonal replacement therapy in order to get monthly withdrawal bleeds and the dose was adjusted, so as to mimic as closely as possible the ovarian steroid profile in a normal ovulatory cycle. She had two trials of ovarian stimulation but no response was seen. Finally the couple decided to go through with an in-vitro fertilization (IVF) treatment using oocyte donation. Pregnancy resulted and proceeded well. Gestation was terminated at the 33rd week by caesarean section and two healthy infants were delivered