rm 28

netics igan the f kineti with molecules are particularly well suited for investigating the other hand, rapid folding is associated with the existence of a folding rates in a set of 24 non-homologous single domain otherwise; N is the total number of contacts and L is the protein chain length. The empirical observation that the CO correlates well with the folding rates of single domain dscapes, strongly Biophysical Chemistry 115 (2smooth, funnel-shaped energy landscape [5]. In [6,7], Plaxcocorrelations between folding times and the native state equilibrium properties, a major challenge for those working in protein research. The energy landscape theory predicts that the landscape’s ruggedness plays a fundamental role in the folding kinetics of model proteins: The existence of local energy minima, that act as kinetic traps, is responsible for the overall slow and, under some conditions (as the temperature is lowered towards the glass transition temperature), glassy dynamics [4]. On the proteins [10]. The CO measures the average sequence separation of contacting residue pairs in the native structure relative to the chain length of the protei