Ovarian Carcinoma In Situ With Germline BRCA1 Mutation and Loss of

for the genesis of cancer predicts that cancer can develop when the wild-type allele of a tumor suppressor gene is lost in an individual with a germline muta-tion in that gene. Neither loss of hetero-zygosity (LOH) for BRCA1 nor muta-tions of the TP53 (also known as p53) gene have been documented prior to invasion in ovarian cancers arising in women with germline BRCA1 muta-tions. Such documentation is difficult because lesions are rarely identified in ovarian epithelium. We, therefore, looked for LOH at microsatellite poly-morphisms linked to the BRCA1 an