ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF MARAVIROC IN BULK AND PHARMACEUTICAL FORMULATION BY UV SPECTROSCOPY

ABSTRACT: The aim of present work is to develop and validate simple, sensitive, economical and accurate Spectrophotometric method has been developed for determination of Maraviroc in pure form and in pharmaceutical formulations. Maraviroc in Phosphate buffer pH 7.4 shows maximum absorbance at 210 nm. Beer’s law was obeyed in the concentration range of 5-25 µg/mL, The LOD and LOQ were found to be 0.10428 μg/ml and 0.315 μg/ml respectively. A recovery of Maraviroc in tablet formulation was observed in the range of 100.70-103.90%. Percentages assay of Maraviroc in tablet was more than 99.73%. The proposed method is precise simple, accurate, precise, economical and robust and can be used for routine analysis of Maraviroc in bulk and pharmaceutical formulations. INTRODUCTION: Maraviroc is one of a new class of antiretroviral drug known as CCR5 antagonists and only oral entry inhibitor approve