FORMULATION DEVLOPMENT AND EVALUATION OF MUCOADHESIVE MICROSPHERE OF LOSARTAN POTASSIUM BY USING NATURAL POLYMER

ABSTRACT: The present work is regarding formulation, development and evaluation of losartan potassium microspheres using natural polymer. The mucoadhesive microspheres of losartan potassium were successfully developed by W/O emulsion solvent evaporation technique using two different natural polymers katira gum and babul gum. Total 12 batches were formulated. Six formulations were prepared by using each natural polymer i.e. LKM1 to LKM6 using katira gum (KG) and LBM1 to LBM6 using babul Gum (BG). All the formulations were evaluated for micromeritic properties, physical evaluation, which includes particle size analysis, percentage yield, drug content, drug entrapment efficacy, percent moisture loss and swelling index, in vitro dissolution studies, in vitro mucoadhesion, scanning electron microscopy, in vitro mucoadhesion and drug polymer interaction studies. The Optimized batch LKM5 was found to release the drug for 12 h (99.78%) and follows Higuchi Matrix mode