Optical holography allows to record tridimensionnal informa-tions of a scene using only one 2D sensor. Physical optics al-lows to analyticaly modelise hologram formation according to objects parameters (position, size, shape...). In simple objects case (e.g. spherical particles), the model is reduced to few pa-rameters (four per particles: x,y,z,radius). Using inverse prob-lem approach, it is possible to determine these parameters re-solving a global optimization problem. This new approach is more efficient than classical method: particle parameters estimation is far more precise and it is possible to localize particles outside of the camera field of view. The presented method achieves to detect particles in an area sixteenth times wider th...