Folate Intake and Pancreatic Cancer Incidence: A Prospective Study of Swedish Women and Men

tion between high folate intake and reduced risk of some cancers, in particular colorectal cancer. However, epidemio-logic data concerning the relationship between folate and pancreatic cancer risk are sparse. We examined the associa-tion between folate intake and risk of pancreatic cancer in a population-based prospective study of Swedish women and men. Methods: We prospectively followed 81 922 women and men in the Swedish Mammography Cohort and the Cohort of Swedish Men who were cancer-free and completed a 96-item food-frequency questionnaire in 1997. Cox proportional hazards models were used to estimate multivariable rate ratios (RRs) with 95 % confi dence intervals (CIs). All statis-tical tests were two-sided. Results: A total of 135 incident pan-creatic cancer cases were diagnosed during a mean follow-up of 6.8 years. In multivariable analyses controlling for age, smoking, fruit and vegetable consumption, and other po-tential confounders, dietary and total folate intakes were statistically signifi cantly inversely associated with risk of pancreatic cancer. The multivariable rate ratios of pancre