STUDIES ON STRUCTURAL PROPERTIES OF THE BINARY MIXTURES OF PHARMACEUTICAL INTERMEDIATES THROUGH DIELECTRIC INVESTIGATIONS

ABSTRACT: The homo and hetero interaction in the binary mixtures of Ethyl acetate + n-Butylamine, Ethyl acetate + Cyclohexylamine and Ethyl acetate + Diethylamine has been investigated through the orientation of dipoles using dielectric polarization method. The dielectric and thermodynamic parameters such as Kirkwood correlation factor, Excess permittivity, Bruggemann factor and Dipolar excess free energy for the above systems have been calculated from the experimentally measured values of capacitance and refractive index of solutions, at temperatures 303K, 313K and 323K.In all the studied systems, the dielectric parameters obtained show systematic change in the molecular structure with the concentration of amine in the solution. It indicates that the β-multimer formation due to the presence of hetero interaction between the components of above mixtures. INTRODUCTION: The pharmaceutical sciences are a group of interdisciplinary areas of stud