ORIGINAL CONTRIBUTION Effect of Disodium EDTA Chelation Regimen on Cardiovascular Events in Patients With Previous Myocardial Infarction The TACT Randomized Trial

for the TACT Investigators TREATMENT OF LEAD TOXICITYwith chelation was first re-ported with EDTA in the early1950s.1 Apparent success in re-ducingmetastatic calciumdeposits2 led Clarke et al3 in 1956 to treat angina pa-tients with EDTA, and others to use chelation for various forms of athero-sclerotic disease.4-6 Chelation therapy evolved to constitute infusions of vita-mins and disodium EDTA, a drug that binds divalent and some trivalent cat-ions, including calcium, magnesium, lead, cadmium, zinc, iron, aluminum, and copper, facilitating their urinary excretion.7,8 Over the next decades, based on fa-vorable anecdotal and case report expe-rience, chelation practitioners in-creased their use of EDTA for coronary and peripheral artery disease. The 2007 National Health Statistics Report com-paredchelationuse since2002andnoted Author Affiliations are listed at the end of this article. A complete list of the TACT Investigators appears in the eAppendix