The Impact of Dietary Calcium on Rates of Breast Cancer Metastasis to Bone

Parathyroid hormone (PTH) is directly involved in breast cancer (BC) metastasis, as well as the severity of metastatic tumors. Excess PTH, caused by insufficient dietary calcium, may be an important and preventable factor affecting BC metastasis to bone. PTH levels increase with age in most women, largely due to insufficient dietary calcium. The goal of the research is to test this hypothesis in non immune-compromised mice that have breast cancer, and are fed diets containing adequate or insufficient calcium