Original Contribution Parental Occupational Exposure to Pesticides and Childhood Germ-Cell Tumors

In a recently completed US case-control study (Children’s Oncology Group, 1993–2001) with 253 cases and 394 controls, the authors investigated the association between parental occupational exposure to pesticides and risk of childhood germ-cell tumors. Information on occupational pesticide exposure was collected using job-specific module questionnaires and assessed by an experienced industrial hygienist. Odds ratios for childhood germ-cell tumors associated with maternal exposures before pregnancy, during pregnancy, and after the birth of the index child were 1.0 (95 % confidence interval (CI): 0.8, 1.4), 1.1 (95%CI: 0.7, 1.6), and 1.3 (95%CI: 0.9, 1.8), respectively. Paternal exposures before pregnancy, during pregnancy, and after the birth of the index child were not related t