Mrons in diabetes-prone NOD mice prevents insulitis and diabetes, despite systemic persis-tence of pathogenic T cell pools. Insulin resis-tance and b cell stress of prediabetic NOD mice are prevented when TRPV1+ neurons are eliminated. TRPV1NOD, localized to the Idd4.1 diabetes-risk locus, is a hypofunctional mutant, mediating depressed neurogenic inflammation. Delivering the neuropeptide substance P by intra-arterial injection into the NOD pancreas reverses abnormal insulin resistance, insulitis, and diabetes for weeks. Concordantly, insulin sensitivity is enhanced in trpv1/mice,whereas insulitis/diabetes-resistant NODxB6Idd4-con-genic mice, carrying wild-type TRPV1, show re
Recently, we identified in normally type 1 diabetes\u96prone NOD/LtJ mice a spontaneous new leptin r...
Recently, we identified in normally type 1 diabetes-prone NOD/LtJ mice a spontaneous new leptin rece...
Type 1A diabetes (autoimmune) is now immunologically predictable in man, but preventable only in ani...
In type 1 diabetes, T cell-mediated death of pancreatic beta cells produces insulin deficiency. Howe...
SummaryIn type 1 diabetes, T cell-mediated death of pancreatic β cells produces insulin deficiency. ...
T-cell responses to insulin and its precursor proinsulin are central to islet autoimmunity in humans...
Key words autoreactive T cell, diabetes mellitus, tolerance, thymic selection Two lines of Ead-expre...
The non-obese diabetic (NOD) mouse is susceptible to the development of autoimmune diabetes but also...
A series of recent studies in humans and the NOD mouse model have highlighted the central role that ...
Diabetes in nonobese diabetic (NOD) mice is a T cell-dependent autoimmune disease. The destructive a...
AbstractPrevious analyses of NOD mice have shown that some genes control the development of both ins...
The non-obese diabetic (NOD) mouse represents a relevant animal model of autoimmunity for insulin-de...
AbstractThe non-obese diabetic (NOD) mouse is susceptible to the development of autoimmune diabetes ...
The non-obese diabetic (NOD) mouse represents a relevant animal model of autoimmunity for insulin-de...
Previous analyses of NOD mice have shown that some genes control the development of both insulitis a...
Recently, we identified in normally type 1 diabetes\u96prone NOD/LtJ mice a spontaneous new leptin r...
Recently, we identified in normally type 1 diabetes-prone NOD/LtJ mice a spontaneous new leptin rece...
Type 1A diabetes (autoimmune) is now immunologically predictable in man, but preventable only in ani...
In type 1 diabetes, T cell-mediated death of pancreatic beta cells produces insulin deficiency. Howe...
SummaryIn type 1 diabetes, T cell-mediated death of pancreatic β cells produces insulin deficiency. ...
T-cell responses to insulin and its precursor proinsulin are central to islet autoimmunity in humans...
Key words autoreactive T cell, diabetes mellitus, tolerance, thymic selection Two lines of Ead-expre...
The non-obese diabetic (NOD) mouse is susceptible to the development of autoimmune diabetes but also...
A series of recent studies in humans and the NOD mouse model have highlighted the central role that ...
Diabetes in nonobese diabetic (NOD) mice is a T cell-dependent autoimmune disease. The destructive a...
AbstractPrevious analyses of NOD mice have shown that some genes control the development of both ins...
The non-obese diabetic (NOD) mouse represents a relevant animal model of autoimmunity for insulin-de...
AbstractThe non-obese diabetic (NOD) mouse is susceptible to the development of autoimmune diabetes ...
The non-obese diabetic (NOD) mouse represents a relevant animal model of autoimmunity for insulin-de...
Previous analyses of NOD mice have shown that some genes control the development of both insulitis a...
Recently, we identified in normally type 1 diabetes\u96prone NOD/LtJ mice a spontaneous new leptin r...
Recently, we identified in normally type 1 diabetes-prone NOD/LtJ mice a spontaneous new leptin rece...
Type 1A diabetes (autoimmune) is now immunologically predictable in man, but preventable only in ani...