DOI: 10.1093/aje/kwf017 Increased Fibrinogen Levels among South Asians versus Whites in the United Kingdom Are Not Explained by Common Polymorphisms

Determinants of fibrinogen level among South Asians are not established. In 1997–1999, plasma fibrinogen levels and prevalences of the fibrinogen polymorphisms Aα Thr312Ala, β-445G/A, and Bβ Arg448Lys and correlates were compared among 100 apparently healthy United Kingdom South Asians and 100 age- and sex-matched Whites. Mean fibrinogen levels were higher in South Asians (3.33 g/liter, 95 % confidence interval (CI): 3.16, 3.51) than in Whites (2.84 g/liter, 95 % CI: 2.72, 2.96) (p < 0.0001), but genotype distributions were similar