ON THE ROLE OF PROOFREADING EXONUCLEASE IN BYPASS OF A BULKY 1,2 D(GPG) CISPLATIN ADDUCT BY THE HERPES SIMPLEX VIRUS-

INTRODUCTION: Translesion synthesis provides a mechanism whereby DNA replication can be completed in the absence of DNA repair often at the expense of fidelity. We previously used a 60:17-mer template primer containing a site-specific 1,2 d(GpG) cisplatin adduct to examine the capacity of the replicative DNA polymerase of herpes simplex virus type-1 (UL30) to perform translesion synthesis in vitro (1). W