Selected DNA repair polymorphisms and gastric cancer in Poland Wen-Yi Huang1,, Wong-Ho Chow1, Nat Rothman1,

Impaired DNA repair capacity may adversely affect cancer risk, particularly in subjects exposed to DNA damaging carcinogens, as found in tobacco smoke, or among subjects deficient for protective factors, as found in fruits and vegetables. We studied tobacco use, fruit and vegetable intake, and common non-synonymous single nucleotide polymorphisms in four DNA repair genes in relation to gastric cancer risk, in a population-based, case--control study of 281 incident gastric cancer cases and 390 controls, in Warsaw, Poland. Multivariate logistic regression ana-lysis was performed to calculate odds ratios (OR) and 95% confidence intervals (CI). Increased risks of gastric cancer were found for smokers (OR 3.1, CI 1.9--5.1 for pack-years 40 versus never smokers) and subjects with low fruit intake (OR 2.2, CI 1.3--3.6 for 1st versus 4t