Coffee consumption and risk of incident gout in men: A prospective study

Objective. Coffee is one of the most widely con-sumed beverages in the world and may affect the risk of gout via various mechanisms. We prospectively evalu-ated the relationship between coffee intake and the risk of incident gout in a large cohort of men. Methods. Over a 12-year period, we studied 45,869 men with no history of gout at baseline. Intake of coffee, decaffeinated coffee, tea, and total caffeine was assessed every 4 years through validated question-naires. We used a supplementary questionnaire to as-certain whether participants met the American College of Rheumatology survey criteria for gout. Results. We documented 757 confirmed incident cases of gout. Increasing coffee intake was inversely associated with the risk of gout. The multivariate rela