Neurofibrillary degeneration in progressive supranuclear palsy and corticobasal degeneration: tau pathologies with exclusively "exon 10" isoforms

Abstract: Pathological tau proteins that constitute the basic matrix of neuronal inclusions observed in numerous neurodegenerative disorders are disease specific. This is mainly the consequence of the aggregation of specific sets of tau isoforms according to the diseases, i.e., six isoforms in Alzheimer’s disease (AD) and exclusively the three tau isoforms lacking the corresponding sequence of exon 10 (E102) in Pick’s disease (PiD). By using anti-bodies specific to the different tau isoforms and one- and two-dimensional gel electrophoresis followed by western blots, we demonstrate herein a third group of neurode-generative disorders characterized by intraneuronal in-clusions exclusively constituted of tau isoforms contain-ing the sequence corresponding to exon 10, progressive supranuclear palsy (PSP) and corticobasal degeneratio