carcinomas treated with platinum-based regimens

Background: The prognostic and predictive value of cell cycle regulatory proteins in ovarian cancer has not been established. We evaluated the clinical and biological significance of P21WAF1, P27KIP1, C-MYC, TP53 and Ki67 expressions in ovarian cancer patients. Materials and methods: Immunohistochemical analysis was performed on 204 ovarian carcinomas of Inter-national Federation of Gynecology and Obstetrics (FIGO) stage IIB to IV treated with platinum-based chemo-therapy. Multivariate analysis with Cox and logistic regression models was performed in the whole group, and in the TP53-negative and TP53-positive subgroups. Results: High P21WAF1 labeling index (LI) was an independent positive predictor of platinum-sensitive response (P = 0.02). Overall survival was positively influenced by P21WAF1 LI (P = 0.02) or by P21WAF1 plu