Formulation and Evaluation of Domperidone Fast Dissolving Tablets.

Abstract: Domperidone, an antiemetic drug, has been used as an add-on treatment in adults and children. As precision of dosing and patient’s compliance become important prerequisite for quick relief from emesis, there is a need to develop a formulation for this drug which overcomes problems such as difficulty in swallowing, inconvenience in administration while traveling and better compliance. Hence, the present research work was held to develop a fast dissolving tablet of domperidone, prepared with Avicel PH 102 and Sodium Starch Glycolate by direct compression method. All formulations were evaluated for characteristics such as hardness, friability, disintegration time and Dissolution rate. An effective, pleasant tasting formulation was found to have a good hardness of 3 kg/cm2, disintegration time of 27+1 seconds and in vitro drug release of not less than 95 % within 30 minutes. The drug release was found to be comparable with the marketed dispersible tablet