Journal of Proteomics & Bioinformatics- Open Access www.omicsonline.com Research Article JPB/Vol.1/December 2008 Imaging Mass Spectrometry and Its Methodological Application to Murine Tissue

Copyright: © 2008 Gustafsson JOR, etal. This is an open-access article distributed under the terms of the Creative Com-mons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Imaging mass spectrometry (IMS) is an emerging technology, pioneered by Prof. Richard Caprioli’s group starting more than a decade ago. In this study we have demonstrated the simplicity of initial technological set up for IMS experiments with commercially available automated matrix deposition, MALDI-TOF mass spectrom-etry instrumentation and data handling software for image generation. We have applied two different concepts of automated matrix deposition on Murine brain sections and discussed their different features and capabilities in IMS. Key words: MALDI; mass spectrometry; imaging; tissue; methodolog