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factor-I (IGF-I); insulin-like growth factor binding protein-3 (IGFBP-3); psoriasis area and severity index (PASI) Neuroendocrinol Lett 2005; 26(6):724–728 PMID: 16380703 NEL260605A09 © Neuroendocrinology Letters www.nel.edu Abstract OBJECTIVES: The serum concentrations of somatotrophin axis hormones (growth hormone – GH, insulin-like growth factor-I – IGF-I and insulin-like growth factor binding protein-3 – IGFBP-3) in the patients with psoriasis in its active stage have been evaluated in relation to the control group consisting of healthy people in order to see whether these hormones may play a role in the psoriasis aetiopathogenesis. MATERIAL AND METHODS: The subjects included 85 psoriatic patients (mean age 36,9 ± 11,2 years) in the active state of disease and 20 healthy persons (mean age 35,6 ± 6,6 years) as a control group. GH and IGFBP-3 concentrations in serum were determined by immunoradiometric assay (IRMA), IGF-I concentrations – by radioimmunological assay (RIA). Evaluation of the dermatological state also included a determination of psoriasis area and severity index (PASI)