The Effects of Circulating Antigen on the Pharmacokinetics and Radioimmunoscintigraphic Properties of 99mTc Labelled Monoclonal Antibodies in Cancer Patients

ABSTRACT Purpose. This article reports the pharmacokinetics, radiation dosimetry and radioimmunoscintigraphy (RIS) of two 99mTc-labelled monoclonal antibodies (MAb) used to detect cancer. Methods: The effects of circulating antigen in female cancer patients are explored and their effects on the ability of these MAbs to effectively perform as RIS agents noted. To illustrate the effects of circulating antigen, data using MAb B43.13 (OVAREX, AltaRex Corp., Waltham, MA, USA) from a Pilot study in ovarian cancer patients are presented. The results from a Phase II study of MAb 170H.82 (Tru