Inference and Reconstruction of Gene regulatory Network in Kaposi’s Sarcoma Associated

In the context of system biology and bioinformatics a central challenge is the re-construction of connections and mechanism of interactions in regulatory profile of gene networks. To understand the structure of biological system, it is important to elucidate the dynamical and casual relationships between transcription factor (TF) proteins and their target genes. In this paper, to address the problem for a regulatory system of dynamic in-teraction among genes of Kaposi’s Sarcoma Associated Herpesvirus (KSHV) net-work after induction of lytic infection, we construct and analyze a dynamic model that captures the kinetics of the representative of its gene network. This module is centered around the replication and transcription activator (Rta) transcription factor, which ectopic over-expression alone is both necessary and sufficient to dis-rupt viral latency and to induce a lytic reaction [1, 2]. We examine the Rta protein activation of a set of target lytic virus genes and also investigate the role of some regulatory proteins that modify the Rta induced expression of these target genes