Ocean-atmosphere interaction over the Northern Hemisphere western boundary current (WBC) regions, i.e. the Gulf Stream, Kuroshio-Oyashio, and their extensions, is reviewed with an emphasis on their role in basin-scale climate variability. SST anomalies exhibit considerable variance on interannual to decadal time scales in these regions. Low-frequency SST variability is primarily driven by basin-scale wind stress curl variability via oceanic Rossby wave adjustment of the gyre scale circulation that modulates the latitude and strength of the WBC-related oceanic fronts. Rectification of the variability by meso-scale eddies, reemergence of the anomalies from the preceding winter, and tropical remote forcing also play important roles in driving ...