Blood Tissue

High myoglobin content and low blood flow in skeletal muscle invalidates the results of the steady-state and bolus [15O]O2 inhalation models developed for brain and myocardium. THEORY We developed a new compartmental model for muscle oxygen studies (fig. 1). Myoglobin bound [15O]O2, and both arterial and venous radioactivity concentrations are included in this model. The extraction of oxygen and water is assumed to be 1. Oxygen consumption i.e. muscle metabolic rate of oxygen (MMRO2) is calculated as blood flow*OER*[O2] in arterial blood