Study Of The Hepatoprotective Activity Of The Ethanolic Extract Of The Pulp Of Eugenia Jambolana (Jamun) In Albino Rats

Objective: To evaluate the hepatoprotective effect of the ethanolic extract of the pulp of Eugenia jambolana (EPEJ) on paracetamol (PCM)-induced hepatotoxicity in albino rats. Materials and Methods: Healthy albino rats (thirty in number) of either sex, weighing 100-150 gms, were randomly divided into five groups of six animals each. Group A (Normal control) and Group B (Paracetamol-treated control) received 5ml/kg/day of 3 % gum acacia; Groups C and D received the ethanolic extract of the pulp of Eugenia jambolana 100mg/kg/day and 200mg/kg/day respectively and Group E received silymarin 100mg/kg/day. All formulations were given orally for ten days. Hepatotoxicity was induced in Groups B, C, D and E by giving a single dose of paracetamol (2gm/kg) orally on the eighthth day of the experiment. Liver function tests (serum levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, total bilirubin, total protein and albumin) and the histopathological examination (HPE) of the liver was done for all the five groups on the tenth day