Add to ORKG(11C-MADAM) is a newly synthesized radioligand with high se-lectivity and specificity for the serotonin transporter (5-HTT) in a monkey model. The purpose of this study in humans was to examine the suitability and potential of 11C-MADAM for quanti-tative PET studies of 5-HTT in applied clinical studies on the pathophysiology and treatment of neuropsychiatric disorders. Methods: PET examination was performed on each of 9 male subjects after intravenous injection of 11C-MADAM with high specific radioactivity. Radioactive metabolites in plasma were determined with high-performance liquid chromatography. A metabolite-corrected arterial input function was used in kinetic 2- and 3-compartment analyses. Cerebellum was used as the reference region ...
The dopaminergic and serotonergic neurotransmission systems are of central interest in relation to s...
Positron Emission Tomography (PET) imaging has become a prominent tool to capture the spatiotemporal...
PET studies of [11C]WAY-100635 binding are proving to be a useful tool to evaluate 5-HT1A receptor f...
The serotonin (5-HT) system attracts considerable attention in research on the pathophysiology and d...
The serotonin (5-HT) system attracts considerable attention in research on the pathophysiology and d...
The serotonin 5-hydroxytryptamine-1 A (5-HT1A)receptor subtype is of central interest in research on...
There has been considerable interest in the development of a PET radioligand selective for the serot...
hydroxymethylphenylthio)benzylamine (11C-HOMADAM) binds with high affinity and selectively to the se...
Objectives: [11C]AFM is a new radioligand for the serotonin transporter which showed higher specific...
A series of four 2-(phenylthio)araalkylamines have been radiolabeled with 11C and evaluated as poten...
N-(2-(4-(2-Methoxy-phenyl)-1-piperazin-1-yl)ethyl)-N-(2-pyridyl)cyclohexanecarboxamide (WAY-100635),...
N-(2-(4-(2-Methoxy-phenyl)-1-piperazin-1-yl)ethyl)-N-(2-pyridyl)cyclohexanecarboxamide (WAY-100635),...
N-(2-(4-(2-Methoxy-phenyl)-1-piperazin-1-yl)ethyl)-N-(2-pyridyl)cyclohexanecarboxamide (WAY-100635),...
The serotonergic system is implicated in several neuropsychiatric disorders, such as depression, anx...
PET studies of [(11)C]WAY-100635 binding are proving to be a useful tool to evaluate 5-HT(1A) recept...
The dopaminergic and serotonergic neurotransmission systems are of central interest in relation to s...
Positron Emission Tomography (PET) imaging has become a prominent tool to capture the spatiotemporal...
PET studies of [11C]WAY-100635 binding are proving to be a useful tool to evaluate 5-HT1A receptor f...
The serotonin (5-HT) system attracts considerable attention in research on the pathophysiology and d...
The serotonin (5-HT) system attracts considerable attention in research on the pathophysiology and d...
The serotonin 5-hydroxytryptamine-1 A (5-HT1A)receptor subtype is of central interest in research on...
There has been considerable interest in the development of a PET radioligand selective for the serot...
hydroxymethylphenylthio)benzylamine (11C-HOMADAM) binds with high affinity and selectively to the se...
Objectives: [11C]AFM is a new radioligand for the serotonin transporter which showed higher specific...
A series of four 2-(phenylthio)araalkylamines have been radiolabeled with 11C and evaluated as poten...
N-(2-(4-(2-Methoxy-phenyl)-1-piperazin-1-yl)ethyl)-N-(2-pyridyl)cyclohexanecarboxamide (WAY-100635),...
N-(2-(4-(2-Methoxy-phenyl)-1-piperazin-1-yl)ethyl)-N-(2-pyridyl)cyclohexanecarboxamide (WAY-100635),...
N-(2-(4-(2-Methoxy-phenyl)-1-piperazin-1-yl)ethyl)-N-(2-pyridyl)cyclohexanecarboxamide (WAY-100635),...
The serotonergic system is implicated in several neuropsychiatric disorders, such as depression, anx...
PET studies of [(11)C]WAY-100635 binding are proving to be a useful tool to evaluate 5-HT(1A) recept...
The dopaminergic and serotonergic neurotransmission systems are of central interest in relation to s...
Positron Emission Tomography (PET) imaging has become a prominent tool to capture the spatiotemporal...
PET studies of [11C]WAY-100635 binding are proving to be a useful tool to evaluate 5-HT1A receptor f...