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Epidermal expression of transforming growth factor-α in transgenic mice: Induction of spontaneous and 12-O-tetradecanoylphorbol-13-acetate-induced papillomas via a mechanism independent of Ha-ras activation or overexpression

Wang, X. J.
Greenhalgh, D. A.
Eckhardt, J. N.
Rothnagel, J. A.
Roop, D. R.

May 1994

To assess the requirements for papilloma formation in transgenic mice that overexpress transforming ...

Synergistic interaction of the Neu proto-oncogene product and transforming growth factor alpha in the mammary epithelium of transgenic mice

Muller, W. J.
Arteaga, C. L.
Muthuswamy, S. K.
Siegel, P. M.
Webster, M. A.
Cardiff, R. D.
Meise, K. S.
Li, F.
Halter, S. A.
Coffey, R. J.

January 1996

This article is hosted on a website external to the CBCRA Open Access Archive. Selecting “View/Open...

Transforming growth factor-a expression is enhanced in human mammary epithelial cells transformed by an activated c-Ha-ras protooncogene but not by the c-neu protooncogene, and overexpression of the transforming growth factor-a complementary DNA leads to

Fortunato Ciardiello
Mary Lou Mcgeady
Nancy Kim
Fulvio Basolo Nancy Hynes
Hiroshi Yokozaki
Toshiaki Saeki
James W. [lliott
Hideo Masui
John Mendelsohn
Herbert Soule
Jose Russo
David S. Salomon

August 2015

MCF-1OA cells are a spontaneously immortalized nor-mal human mammary epithelial cell line. MCF-1OA c...

Proliferation of Estrogen Receptor alpha Positive Mammary Epithelial Cells is Restrained by TGFbeta1 in Adult Mice

Ewan, Kenneth B.R.
Oketch-Rabah, Hellen A.
Ravani, Shraddha A.
Shyamala, G.
Moses, Harold L.
Barcellos-Hoff, Mary Helen

March 2005

Transforming growth factor {beta}1 (TGF{beta}1) is a potent inhibitor of mammary epithelial prolifer...

Transformation of mouse mammary epithelial cells with the Ha-ras but not with the neu oncogene results in a gene dosage-dependent increase in transforming growth factor-α production

Ciardiello, Fortunato
Hynes, Nancy
Kim, Nancy
Valverius, Eva M.
Lippman, Marc E.
Salomon, David S.

July 1989

AbstractAn enhanced expression of transforming growth factor-α (TGFα) was demonstrated in two clones...

Targeted Overexpression of Transforming Growth-Factor-Alpha in the Epidermis of Transgenic Mice Elicits Hyperplasia, Hyperkeratosis, and Spontaneous, Squamous Papillomas

Dominey, A. M.
Wang, X. J.
King, L. E.
Nanney, L. B.
Gagne, T. A.
Sellheyer, K.
Bundman, D. S.
Longley, M. A.
Rothnagel, J. A.
Greenhalgh, D. A.
Roop, D. R.

December 1993

To assess the effects of transforming growth factor alpha (TGF-alpha) on mammalian skin in vivo, we ...

Regulation of surface-differentiation molecules by epidermal growth factor, transforming growth factor alpha, and hydrocortisone in human mammary epithelial cells transformed by an activated c-Ha-ras proto-oncogene

BASOLO F
SERRA C
CIARDIELLO F
FIORE L
RUSSO J
CAMPANI D
DOLEI A
SQUARTINI F
TONIOLO A

January 1992

Spontaneously immortalized human mammary epithelial cells MCF-10A were transfected with an activated...

Oncogenic Transformation of Mammary Epithelial Cells by Transforming Growth Factor Beta Independent of Mammary Stem Cell Regulation

Dunphy, Karen
Seo, Jae-Hong
Kim, Daniel J
Roberts, Amy L
Tao, Luwei
DiRenzo, James
Balboni, Amanda L
Crisi, Giovanna M
Hagen, Mary J
Chandrasekaran, Thiruppavai
Gauger, Kelly J
Schneider, Sallie Smith
Jerry, D Joseph

January 2013

Background: Transforming growth factor beta (TGFβ) is transiently increased in the mammary gland dur...

Epidermal expression of transforming growth factor-α in transgenic mice: Induction of spontaneous and 12-O-tetradecanoylphorbol-13-acetate-induced papillomas via a mechanism independent of Ha-ras activation or overexpression

Wang, X. J.
Greenhalgh, D. A.
Eckhardt, J. N.
Rothnagel, J. A.
Roop, D. R.

May 1994

To assess the requirements for papilloma formation in transgenic mice that overexpress transforming ...

Transforming growth factor-a expression is enhanced in human mammary epithelial cells transformed by an activated c-Ha-ras protooncogene but not by the c-neu protooncogene, and overexpression of the transforming growth factor-a complementary DNA leads to

Fortunato Ciardiello
Mary Lou Mcgeady
Nancy Kim
Fulvio Basolo Nancy Hynes
Hiroshi Yokozaki
Toshiaki Saeki
James W. [lliott
Hideo Masui
John Mendelsohn
Herbert Soule
Jose Russo
David S. Salomon

August 2015

MCF-1OA cells are a spontaneously immortalized nor-mal human mammary epithelial cell line. MCF-1OA c...

Transformation of mouse mammary epithelial cells with the Ha-ras but not with the neu oncogene results in a gene dosage-dependent increase in transforming growth factor-α production

Ciardiello, Fortunato
Hynes, Nancy
Kim, Nancy
Valverius, Eva M.
Lippman, Marc E.
Salomon, David S.

July 1989

AbstractAn enhanced expression of transforming growth factor-α (TGFα) was demonstrated in two clones...

Targeted Overexpression of Transforming Growth-Factor-Alpha in the Epidermis of Transgenic Mice Elicits Hyperplasia, Hyperkeratosis, and Spontaneous, Squamous Papillomas

Dominey, A. M.
Wang, X. J.
King, L. E.
Nanney, L. B.
Gagne, T. A.
Sellheyer, K.
Bundman, D. S.
Longley, M. A.
Rothnagel, J. A.
Greenhalgh, D. A.
Roop, D. R.

December 1993

To assess the effects of transforming growth factor alpha (TGF-alpha) on mammalian skin in vivo, we ...

Regulation of surface-differentiation molecules by epidermal growth factor, transforming growth factor alpha, and hydrocortisone in human mammary epithelial cells transformed by an activated c-Ha-ras proto-oncogene

BASOLO F
SERRA C
CIARDIELLO F
FIORE L
RUSSO J
CAMPANI D
DOLEI A
SQUARTINI F
TONIOLO A

January 1992

Spontaneously immortalized human mammary epithelial cells MCF-10A were transfected with an activated...

Oncogenic Transformation of Mammary Epithelial Cells by Transforming Growth Factor Beta Independent of Mammary Stem Cell Regulation

Dunphy, Karen
Seo, Jae-Hong
Kim, Daniel J
Roberts, Amy L
Tao, Luwei
DiRenzo, James
Balboni, Amanda L
Crisi, Giovanna M
Hagen, Mary J
Chandrasekaran, Thiruppavai
Gauger, Kelly J
Schneider, Sallie Smith
Jerry, D Joseph

January 2013

Background: Transforming growth factor beta (TGFβ) is transiently increased in the mammary gland dur...

Epidermal expression of transforming growth factor-α in transgenic mice: Induction of spontaneous and 12-O-tetradecanoylphorbol-13-acetate-induced papillomas via a mechanism independent of Ha-ras activation or overexpression

Wang, X. J.
Greenhalgh, D. A.
Eckhardt, J. N.
Rothnagel, J. A.
Roop, D. R.

May 1994

To assess the requirements for papilloma formation in transgenic mice that overexpress transforming ...