Cell Stem Cell, Volume 2 Supplemental Data Module Map of Stem Cell Genes Guides Creation of Epithelial Cancer Stem Cells

(A) Human stem cell gene module map: a matrix of gene sets (rows) versus expression arrays (columns), where a red (or green) entry indicates that the individual genes within the gene set are significantly induced (or repressed) in the expression array more than expected by chance (FDR<0.05, p<0.001). The intensity of each entry corresponds to the average fold change of all of the genes within the gene set in the array. The arrays are labeled as differentiated cells or the type of stem cell. A subset of significant gene sets is shown; redundant gene sets were removed for clarity. Gene sets defined by gene ontology terms are listed in black; published gene sets defined by expression arrays of stem cells and differentiated cells are listed in purple; gene set defined by genome-wide chromatin immunoprecipitation experiments is listed in blue. Note the clustering of the arrays of ESCs and embryonal carcinomas, labeled “ESC-like”. (B) Venn diagram displaying the genes conserved between the ESC-like gene modules in mouse and human